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Migraine Science
Research breakdowns, treatment guides and myth-busting, written in plain language with the studies linked. No paywalls, ever.
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Articles, page 8
How migraine works
Cortical Spreading Depression Video Study Guide
A study guide on cortical spreading depression, the brain wave behind aura.
CGRP
A Breakthrough on the Horizon: PACAP-Targeting Antibodies Offer New Promise for Migraine Prevention
Early trials of Lu AG09222, an antibody against PACAP, show promise for prevention.
How migraine works
New Study Maps Migraine Symptoms Across Attack Phases
A 2024 study mapped how common 29 symptoms are across each migraine phase.
How migraine works
White Matter Lesions in Migraine Patients: What You Need to Know
What white matter lesions mean for people with migraine, based on current research.
CGRP
Gepant Adverse Events Chart
Real-world data on the side effects people report with gepants.
How migraine works
Patent Foramen Ovale and Migraine
The link between a patent foramen ovale and migraine, and what it means for stroke risk.
Devices
My Experience with HeadaTerm 2: The most affordable FDA-approved neuromodulation device
HeadaTerm 2
How migraine works
New Insights into Migraine Pathophysiology
A visual guide to how cortical spreading depression sets off migraine pain.
Buyer's guide
Unraveling Migraine: A Comprehensive Guide to Understanding and Managing A Complex Neurological Disease
Our 150-page guide to understanding and managing migraine, in print.
CGRP
Migraine Attacks Independent of CGRP (cGMP-mediated migraine)
Sildenafil triggered attacks even with CGRP blocked, pointing to a cGMP pathway.
Aura
Migraine Aura vs TIA
How to tell migraine aura from a TIA, and the red flags that need urgent care.
Lifestyle and triggers
The Migraine Brain Does NOT Like Routine: Do you want to win the battle or the war?
A study suggests strict routine may not help chronic migraine in the long run.
CGRP
Cardiovascular Safety of Anti-CGRP Monoclonal Antibodies in Migraine Treatment
In one study, about 3% on CGRP antibodies had ECG changes or heart-related events.
Aura
Galanin: A Promising New Treatment for Migraine with Aura
In lab studies, galanin reduced the brain waves behind aura, a possible new target.
Prevention
Debunking the Myth: Potassium as a Migraine Treatment
Social media claims about potassium as a migraine treatment, checked against the science.
CGRP
The Promise and Challenges of CGRP as a Migraine Biomarker
Why CGRP is a promising but tricky blood marker for diagnosing and tracking migraine.
Research news
Study Finds Acid Reflux Medications Linked to Higher Risk of Migraine and Severe Headache
Acid reflux drugs, especially PPIs, were linked to higher migraine risk in one study.
Devices
HeadaTerm 2: An Affordable FDA-Cleared Alternative to Cefaly for Migraine Relief
HeadaTerm 2 is an FDA-cleared device similar to Cefaly at a fraction of the price.
How migraine works
MRI Study Reveals Brain Differences in Patients with Migraine, Offering Hope for Better Diagnostics and Treatment
An MRI study found brain differences in migraine that may help future diagnosis.
Headache types
Migraine Medication Underuse: How Insufficient Treatment Can Lead to Chronic Migraine
Using too little acute or preventive treatment can push migraine toward chronic.
Lifestyle and triggers
The Relationship Between Comorbid Sleep Problems, Central Sensitization, and Headache-Related Disability in Migraine Patients
How sleep problems, central sensitization and disability are linked in migraine.
CGRP
What is the optimal duration of treatment with anti-CGRP mAbs to determine their efficacy for each individual patient?
How long to try a CGRP antibody before deciding whether it works for you.
Headache types
Deep Dive into the Pathophysiology of Trigeminal Autonomic Cephalalgias
How cluster headache and other TACs arise, from the trigeminal reflex to the hypothalamus.
Research news
