MigraineScience

Unraveling Migraine: A Comprehensive Guide to Understanding and Managing A Complex Neurological Disease

A randomized, double-blind, placebo-controlled study published in Cephalalgia investigated whether sildenafil (Viagra), a phosphodiesterase-5 (PDE-5) inhibitor that increases cGMP levels, could induce migraine attacks in individuals with migraine who were pre-treated with...

It can sometimes be difficult to distinguish between migraine aura and TIA, especially in cases of hemiplegic migraine, migraine with brainstem aura, or retinal migraine. Pay close attention to the...

Many in the migraine community have heard the common phrase "the migraine brain loves routine." However, a recent study suggests that this advice, while potentially helpful in the short-term, may...

The researchers discovered that 3.1% of participants experienced abnormal ECGs or cardiovascular adverse events. Among these, 1.6% encountered more severe complications, such as cerebellar stroke, spontaneous coronary artery dissection, or...

A recent study has found that galanin, a neuropeptide, may be a potential new treatment target for migraine with aura. Galanin significantly reduced the severity and spread of cortical spreading depolarizations...

It's that time again. New misinformation on social media claiming potassium to be a migraine treatment. It is crucial to separate facts from fiction when it comes to the role...

While diagnosis and treatment monitoring of migraine disease largely rely on patient-reported symptoms, the discovery of calcitonin gene-related peptide (CGRP) as a potential biomarker has sparked hope for a more...

A recent study indicates that acid reflux medications, particularly proton pump inhibitors (PPIs), may be associated with a higher risk of migraine and severe headache. Learn about the study's key...

Get HeadaTerm 2 Now If you have migraine disease, you may have heard of Cefaly - the popular FDA-approved device that uses external trigeminal nerve stimulation (eTNS) technology to prevent...

Discover the fascinating findings of a recent MRI study that sheds new light on the brain's inner workings in individuals with migraine, offering hope for better understanding and treatment of...

While effective acute and preventive migraine medications are available, many patients experience migraine progression and chronification due to insufficient, ineffective, or intolerable use of these treatments. This phenomenon, termed "medication...

Explore the intricate associations between comorbid sleep problems, central sensitization, and headache-related disability in migraine patients. Learn about the prevalence of sleep disorders in migraine, their impact on migraine severity,...

What is the optimal duration of treatment with anti-CGRP mAbs to determine their efficacy for each individual patient?

 Explore the complex pathophysiology of trigeminal autonomic cephalalgias (TACs), including the role of the trigeminal autonomic reflex, hypothalamic activation, neuropeptides, and autonomic symptoms. Understand how these mechanisms contribute to the...

DISCLAIMER: THIS WAS FOR APRIL FOOLS DAY FOR 2024!!!! In a stunning development, the chiropractic community has leapfrogged ahead of neurologists and headache specialists to become the undisputed experts in...

Cluster Headache Treatment: Acute and Preventive

The Dangers of Pain Reprocessing Therapy for Patients with Migrane: Why PRT is Not a Viable Treatment Option

While the exact pathways are unclear, there is evidence of dysfunction in both sympathetic and parasympathetic systems in migraine, with a trend towards relative sympathetic impairment interictally and hyperresponsiveness ictally....

The Truth About "Safety-Coated" NSAIDs for Migraine