Migraine Science
New Insights into Migraine Pathophysiology
Posted on July 06 2024,
Stay in the Loop on the Latest in Migraine:
CSD Phase
Cortical Spreading Depression (CSD)
CSD Phase
Wave of Brain Activity Suppression
NEW
CSF Phase
CSF Proteome Alterations
~11% of CSF proteome altered after CSD
CSF Phase
Up-regulation of Trigeminal-activating Proteins
CSF Phase
CGRP in CSF
Known to increase during migraine attacks
NEW
Trigeminal Phase
CSF Flow into Trigeminal Ganglion
Newly discovered pathway for pain signaling
NEW
Trigeminal Phase
New Zone without Epineural Sheath
Area in trigeminal ganglion allowing direct CSF contact
NEW
Trigeminal Phase
Nonsynaptic Brain-Trigeminal Signaling
Direct communication between the CNS and PNS via CSF
Trigeminal Phase
Altered CSF Contacts Trigeminal Neurons
Pain Phase
Activation of Trigeminal Nerve Cells
Pain Phase
Headache/Migraine Pain
Pain Phase
Migraine Attack Symptoms Experienced
Resolution Phase
Temporary Process
Resolution Phase
CSF Proteome Normalizes
Resolution Phase
Decrease in Pain Signals
Resolution Phase
Migraine Attack Subsides
Reference: Rasmussen et al. (2024). Cortical spreading depression opens a paravascular space in the trigeminal ganglion. Science, 385(6320), 80-85. DOI: 10.1126/science.adq3498
Tue, Sep 08, 26
Botox for Chronic Migraine: What 479 Real-World Patients Show
A 479-patient real-world study of onabotulinumtoxinA for chronic migraine found a mean reduction of 5.9 monthly headache days, with 27.3% reaching the 50% response threshold and 41.6% shedding medication overuse....
Read MoreWed, Sep 02, 26
The New Migraine Prevention Guideline: What the AAN and AHS Recommend
The American Academy of Neurology and the American Headache Society have published a joint practice guideline on migraine prevention in adults: 17 recommendations and 52 statements. It names no single...
Read More
Thu, Aug 27, 26
Migraine Research News: The Best Place to Follow New Migraine Studies Daily
Migraine research moves every week and almost none of it reaches the people who have migraine. Today in Migraine Science is a free page, updated daily, that summarizes the newest...
Read More
Latest posts
Migraine science on Instagram
New research broken down in plain language, most days of the week.
Follow @cerebral_torque
