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Medication Overuse Headache (MOH) AKA Rebound Headache Treatment Has Changed- MOTS Trial
The MOTS trial changed how medication overuse (rebound) headache is treated: starting a preventive without forced withdrawal worked as well.
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Medication Overuse/Adaptation Headache
Comprehensive guide to medication overuse headache (MOH/MAH): understand causes, symptoms, and evidence-based treatments. Learn about CGRP therapies, withdrawal protocols, prevention strategies, and breakthrough research showing detox...
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How COVID-19 Changes Migraine Patterns
COVID-19 worsens migraine patterns in patients with pre-existing migraines, causing increased frequency, severity, and treatment resistance. New research reveals 6 of 7 patients experienced major changes...
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Retinal Migraine: Vision Loss in One Eye Explained
Retinal migraine causes brief vision loss in one eye. Learn how to tell it apart from a stroke, how it is diagnosed, which triggers matter, and...
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Comparison of Trigeminal Autonomic Cephalalgias: Cluster Headache vs Paroxysmal Hemicrania vs SUNCT and SUNA vs Hemicrania Continua
Cluster Headache vs Paroxysmal Hemicrania vs SUNCT and SUNA vs Hemicrania Continua
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Milnacipran for Migraine (uncommon preventive drug series)
Milnacipran is an SNRI sometimes used off-label for migraine prevention, especially with fibromyalgia. How it works, the evidence, and side effects.
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Duloxetine (Cymbalta): A Potential Off-Label Treatment for Migraine
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI). Therefore, it inhibits the reuptake of serotonin and norepinephrine.
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Migraine Pathophysiology
Comprehensive guide to migraine pathophysiology: brain mechanisms, CGRP pathway, cortical spreading depression, triggers, genetics, and how understanding migraine science guides modern treatments like CGRP inhibitors and...
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Migraine: Men Vs Women
Sex-Based Differences in Migraine
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Rimegepant for Migraine Prevention: Real-World Evidence
New real-world data on rimegepant for migraine prevention: a 75 mg every-other-day gepant that also treats attacks. What the GEMA study found on response rates, dosing,...
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Venlafaxine (Effexor): A Potential Off-Label Treatment for Migraine
Venlafaxine (Effexor): A Potential Off-Label Treatment for Migraine Prevention
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CGRP and Migraine: The Molecule and the New Drugs
CGRP is the molecule behind the newest migraine drugs. What CGRP is, how it triggers an attack, and how anti-CGRP antibodies and gepants prevent or stop...
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Migraine Management During Pregnancy, Breastfeeding, and Pregnancy Planning
This guide provides comprehensive, evidence-based recommendations for migraine management throughout the reproductive journey.
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Desvenlafaxine (Pristiq): A Potential Off-Label Treatment for Migraine
Desvenlafaxine is a potent metabolite of venlafaxine, another SNRI, which we talked about previously.
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How Much Is Too Much Excedrin Migraine? (MWS Day 2)
How Much Is Too Much Excedrin Migraine?
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Atogepant for Migraine Prevention: What the Data Shows
A new meta-analysis of 6 randomized trials and 3,453 people shows how much atogepant actually reduces monthly migraine days, which dose works best, and what side...
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Understanding The Migraine-Cardiovascular Connection
Discover the surprising connection between migraine and cardiovascular health in our latest article. New research reveals how migraine, especially with aura, affects heart health differently than...
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Dizziness and Migraine: When is it Vestibular Migraine?
Dizziness and migraine: Learn when dizziness is vestibular migraine vs BPPV, Meniere's disease, or vascular causes. Guide covers symptoms, diagnosis, cutaneous allodynia, and treatment options for...
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Migraine and Headaches During Pregnancy & Postpartum
Comprehensive guidance on managing migraine and headaches during pregnancy and postpartum. Learn about effective treatments, safety considerations, and when to seek medical help. Discover evidence-based strategies...
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New Research Shows Migraine Patients with Medication Overuse/Adaptation Headache May Have Leaky Gut
A Journal of Headache and Pain study links chronic migraine with medication overuse headache to markers of leaky gut. Key findings and limitations.
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The Dangers of Pain Reprocessing Therapy for Patients with Migraine: Why PRT is Not a Viable Treatment Option
The Dangers of Pain Reprocessing Therapy for Patients with Migrane: Why PRT is Not a Viable Treatment Option
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Medication Overuse Headache aka Medication Adaptation Headache aka Rebound Headache: A Comprehensive Guide
A clinical guide to medication overuse headache, also called medication adaptation or rebound headache: causes, diagnosis, withdrawal, and prevention.
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Answers to Key Questions for Peter Goadsby, MD, PhD, FRS on the Topic of Migraine Biochemistry: CGRP & Beyond (Migraine World Summit - Day 2)
Key Questions for Peter Goadsby, MD, PhD, FRS on the Topic of Migraine Biochemistry: CGRP & Beyond (Migraine World Summit - Day 2)
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Migraine Science Archive 2026
Older entries from Today in Migraine Science: plain-language summaries of migraine studies, guidelines and news, each linked to its source.
