MigraineScience

The zinc-dependence of botulinum toxin protease activity provides the rationale for zinc supplementation. By increasing the available zinc within the nerve terminal at the time of toxin internalization, the idea...

There are no accepted, universal diagnostic criteria for refractory migraine or resistant migraine in the International Classification of Headache Disorders, 3rd edition (ICHD-3).

Caffeine has complex effects on migraine, with the ability to trigger attacks in susceptible individuals or provide symptom relief in others. Let’s talk about the pharmacology of caffeine, mechanisms of...

This post is for educational purposes only and may contain errors. Please talk to your neurologist.  Vitamin B12 is a water-soluble B vitamin that has roles in DNA and red...

Migraine surgery involves decompressing various nerves in the face and head that are proposed to trigger migraine attacks. Proponents argue that decompressing these trigger sites can prevent migraine attacks or...

Nummular headache is head pain localized to a small, circumscribed coin-sized area - thus coining (no pun intended) the alternate term “coin-shaped headache.”

Obstructive sleep apnea (OSA) is a common sleep disorder that consists of repeated pauses in breathing during sleep. One common symptom associated with sleep apnea is morning headache aka sleep...

What is Epicrania Fugax? Epicrania fugax is a primary headache disorder characterized by brief stabbing head pain that rapidly moves in a linear or zig-zag pattern across one side of...

How often do you think about the Roman Empire? There is a fascinating trend currently on TikTok in which women record men responding to the question, "How often do you...

Almost Everything You Need To Know About Migraine During Pregnancy

Clinical Features VS Anti-CGRP Treatment Response

Primary stabbing headache is also known as ice pick headache, ice pick pain, idiopathic stabbing headache, ophthalmodynia periodica, needle-in-eye syndrome, sharp short-lived head pain, and jabs and jolts syndrome.

Evidence-Based Pharmacological Treatment of Acute Migraine in the Emergency Department

This post is for educational purposes only and may contain errors. Please talk to your neurologist. Acute migraine pharmaceutical treatment cheat sheet: Acetaminophen This is Tylenol. 1000 mg PO recommended....

Hypnic headache, previously termed “alarm clock” headache, is an uncommon primary headache disorder that is underdiagnosed and poorly characterized.