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Migraine Science
Research breakdowns, treatment guides and myth-busting, written in plain language with the studies linked. No paywalls, ever.
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Acute treatment
Opioids as the First ER Treatment for Headache: What a 13,285-Person Study Found
In 13,285 adults treated for headache in the ER, those given opioids first were more likely to come back within 72 hours than those given guideline-preferred drugs.Free migraine tools
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Add it upBuyer's guides
How to choose a migraine roller, book or tracker, including the ones we make.
Buyer's guide
Why I Made Unraveling Migraine Free on Amazon
Buyer's guide
CROWN vs CROWN Plus: which cooling roller is right for you
Buyer's guide
Strongest migraine roll-on: a buyer's guide to maximum-strength cooling rollers
Buyer's guide
The quiet ingredients in CROWN Plus
Buyer's guide
The science behind CROWN Plus: how maximum cooling works
Buyer's guide
The Best Migraine Stick: A Buyer's Guide to Migraine and Headache Sticks
Buyer's guide
The Best Migraine Relief Roll On: A Buyer's Guide to Roll Ons for Migraine
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The Best Migraine Tracker Journal: How to Pick One Your Neurologist and Insurer Will Actually Use
Buyer's guide
The Best Book on Migraine: How to Choose One That's Actually Worth Reading
More from MigraineScience
Women's health
Migraine, Heart Attack, and Stroke Before and After Menopause: What a 2.2 Million-Woman Study Found
In 2.2 million Korean women, migraine was tied to more heart attacks and ischemic strokes before and after menopause, with a larger relative increase before and more extra events after.
CGRP
Raising the Eptinezumab (Vyepti) Dose to 300 mg: What a Study of Partial Responders Found
A real-world study followed 57 people who only partly responded to eptinezumab (Vyepti) 100 mg. After moving up to 300 mg, about two in three reached a 50% drop in headache days.
Prevention
Vitamins and Supplements for Migraine Prevention: What a 20-Trial Network Meta-Analysis Found
A new network meta-analysis of 20 double-blind trials ranks vitamins and supplements for migraine prevention. Riboflavin 400 mg had the most reliable evidence, and magnesium showed no benefit.
Women's health
Does Migraine Go Away After Menopause? What a 315-Woman Study Found
In a clinic study of 315 women with migraine before menopause, 219 still had attacks afterward, though fewer and milder. A family history of migraine and insomnia were linked to migraine continuing.
Prevention
Memory and Concentration Problems With Migraine: Do They Improve When Prevention Works?
In 96 adults starting a CGRP antibody or Botox, people whose migraine responded reported a bigger improvement in memory and concentration complaints than people whose migraine did not.
CGRP
Does Rimegepant (Nurtec ODT) Work Every Time? What a 377-Attack Study Found
In 191 people who logged 377 migraine attacks, rimegepant (Nurtec ODT) gave pain freedom at 2 hours in 45% of attacks. For most people, the response changed from one attack to the next.
Research news
Acrylamide in Migraine Ice Caps: What Two New Studies Found
Two 2026 studies found acrylamide, a nerve toxin, at thousands of ppm in the gel of some migraine ice caps. Here is what that means for people who wear them and what the brands disclose.
Lifestyle and triggers
Exercise and Migraine: What a 1,828-Person Study Found
In a survey of 1,828 people with migraine, about a quarter said exercise triggers headache and a quarter said it eases headache. Frequent attacks, allodynia, and anxiety shaped who reported which.
CGRP
CGRP Migraine Drugs and Blood Pressure: What a 6,361-Patient Study Found
A 6,361-patient study found CGRP migraine preventives did not raise blood pressure faster than in similar patients not taking them. Atogepant (Qulipta) users also lost the most weight.
Acute treatment
How Migraine Is Treated After Diagnosis in the US: What a 154,353-Person Study Found
Nearly half of US adults newly diagnosed with migraine filled an opioid prescription within 3 years, while fewer than 1 in 10 started prevention with a CGRP antibody.
Lifestyle and triggers
Pets and Migraine: What a 3,017-Person, 2-Year Study Found
A 2-year study of 3,017 people with migraine found pet owners, especially dog owners, had fewer and milder attacks. Here is what that means and why it does not prove pets are the cause.
Lifestyle and triggers
Plastic Surgeons Are Pushing Hard for Migraine Surgery Right Now. Read This Before Anyone Operates on You.
Plastic surgeons published four pro-surgery pieces in seven weeks, one calling the evidence settled and one urging nose surgery for migraine. Here is what they leave out before you agree to anything.
Prevention
Migraine and Glaucoma: What a 3.6 Million-Person Meta-Analysis Found
A meta-analysis of 19 studies and 3.6 million people linked migraine to modestly higher odds of glaucoma, a silent cause of vision loss. The link was smallest in the largest studies.
Women's health
CGRP Migraine Injections and Miscarriage Risk: What a New JAMA Neurology Study Found
A JAMA Neurology study of 7,579 pregnancies linked CGRP antibody injections in early pregnancy to a higher miscarriage rate. Propranolol showed no link, which matters for anyone planning a pregnancy.
Acute treatment
Opioids for Migraine: What a 12,612-Person International Survey Found
A survey of 12,612 people with migraine in six countries found nearly 1 in 4 used opioids for headache. Users reported more disability and four times the ER and hospital visits, though cause is unclear.
Acute treatment
Can a Wearable Predict a Migraine Attack? What a New Wrist-Sensor Study Found
A new Cephalalgia study paired a wrist-worn sensor with personalized machine learning and flagged pre-attack periods 2 to 12 hours before the headache started in most participants. A single model for everyone worked f...
CGRP
Hair Loss and CGRP Migraine Drugs: What the Evidence Shows
A 2026 review gathered every published report of hair loss on CGRP antibodies and gepants. The signal is consistent across the class, the hair loss is usually mild diffuse shedding that reverses after stopping, and th...
CGRP
