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TorqueGlide: A Topical Gel Roller for Neurological Support and Pain Relief

Posted on July 30 2023, By: Cerebral Torque

TorqueGlide

Advanced Topical Gel Roller for Migraine and Chronic Pain Relief

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TorqueGlide Product

TorqueGlide combines powerful natural ingredients for effective pain relief

Migraine and chronic pain conditions can significantly reduce quality of life. TorqueGlide is a topical gel roller designed to provide neurological support and pain relief through a blend of research-backed natural ingredients. We will examine the key ingredients in TorqueGlide and analyze the current research of their mechanisms and efficacy for pain relief.

NEW

Enhanced Formula: Now with CBD BSO and CBG

We're excited to announce that TorqueGlide has been enhanced with 1000 mg CBD BSO (Broad Spectrum Oil) and 1000 mg CBG (Cannabigerol) to provide even more effective support for individuals with migraine and chronic pain conditions.

The gel roller delivery method allows the active ingredients to be directly absorbed through the skin for localized effects. The rollerball applicator cools on contact for additional migraine and pain relief. Using TorqueGlide involves simply rolling the applicator over the affected area to apply the active formula (please see the instructions for more detail).

The ingredients work through various mechanisms when absorbed via the transdermal route. These include gate control theory of pain, counterirritation, anti-inflammatory effects, antioxidant properties, and modulation of pain signaling pathways. Current evidence indicates TorqueGlide's potential as an integrative topical therapy to reduce migraine, chronic and acute pain, and support overall neurological health.

The Science Behind TorqueGlide's Effectiveness

TorqueGlide works through multiple mechanisms of action to provide comprehensive pain relief:

  1. Gate Control Theory - Non-painful stimuli compete with and block pain signals
  2. Counterirritation - One sensation reduces another through competing nerve signals
  3. Anti-inflammatory Effects - Reduces inflammation at the site of application
  4. Endocannabinoid System Modulation - Supports natural pain regulation pathways

Understanding the Gate Control Theory and Counterirritation

Several of the ingredients in TorqueGlide work through the gate control theory of pain. This theory, first proposed in 1965 by Ronald Melzack and Patrick Wall [1], suggests that pain perception is not a direct result of nociceptive (pain) signaling, but is modulated by interaction between nociceptive inputs and non-nociceptive inputs in the spinal cord [2]. Essentially, "gates" in the spinal cord can increase or decrease pain signaling to the brain based on the relative amounts of nociceptive and non-nociceptive input. Non-nociceptive input "closes the gates" and prevents pain signals from reaching the brain. We know this instinctually. It is why we hold a toe we just stubbed or rub on an acutely painful injury.

Another relevant mechanism is counterirritation, which refers to the process of using one irritant stimulus to reduce the sensation of another irritant. For example, applying heat or cold to an injured area activates nerve fibers that compete with and partially override pain signals, providing temporary pain relief [2].

Key Ingredients in TorqueGlide

Menthol

Menthol is known to activate transient receptor potential cation channel subfamily M member 8 (TRPM8) receptors, which are cold-sensitive and provide a cooling sensation [3]. This activation provides non-nociceptive input that can "close the gate" to pain signals. Menthol has been shown in studies to reduce migraine pain, allodynia (pain from stimuli that do not normally cause pain), musculoskeletal pain, neuropathic pain, and pain from sports injuries [4,5].

The percentage of menthol used is also crucial as "low to moderate concentrations of menthol activate TRPM8 in the primary nociceptors, such as dorsal root ganglion (DRG) and trigeminal ganglion, generating a cooling sensation, whereas menthol at higher concentration could induce cold allodynia, and cold hyperalgesia mediated by TRPM8 sensitization" [6]. TorqueGlide uses just the right percentage of menthol to achieve pain relief without causing cold allodynia or hyperalgesia.

Curcumin C3 Complex®

Curcumin is the main active compound in turmeric that has demonstrated anti-inflammatory and antioxidant properties in studies [7]. Curcumin C3 Complex® is a patented composition containing three potent curcuminoids - curcumin, bisdemethoxycurcumin, and demethoxycurcumin.

Research shows topical curcumin, like that in TorqueGlide, has anti-inflammatory and antioxidant effects on skin [8,9]. It reduces levels of CGRP, a neuropeptide involved in migraine pain [10]. In clinical trials, topical curcumin gel had similar efficacy to ibuprofen for the treatment of knee arthritis, but with fewer gastrointestinal symptoms [11]. It also decreased joint pain in knee osteoarthritis comparable to diclofenac [12].

A meta-analysis study has also found that curcumin is associated with beneficial effects on the skin, including, but not limited to, an increase in skin moisture, prevention of chronic ultraviolet B damage, and prevention of facial redness from rosacea or flushing [13]. The transdermal application of curcumin protects the skin by neutralizing free radicals, reducing inflammation through the inhibition of nuclear factor-kappa B, and affecting other signaling pathways like transforming growth factor-β and mitogen-activated protein kinase pathway. It also modulates phase II detoxification enzymes, crucial for detoxification reactions and protection against oxidative stress [14].

BioPerine®

BioPerine is a patented black pepper extract containing 95% piperine. Piperine enhances the absorption and bioavailability of other compounds like curcumin [15]. Like menthol, BioPerine in TorqueGlide may provide pain relief via the gate control theory of pain without the potential of skin irritation [15].

Boswellia Serrata Extract

Boswellia serrata produces resin that contains active phytochemical compounds including boswellic acids. Boswellia extract has been used for centuries for its anti-inflammatory effects. Recent research has further explored the pharmacological actions and therapeutic potential of Boswellia serrata extract.

Studies demonstrate that Boswellia extract exhibits neuroprotective qualities. The boswellic acids appear to modulate inflammatory pathways and prevent oxidative damage in the brain [16]. This neuroprotective effect may have implications for treating neurodegenerative disorders.

Applied topically, Boswellia extract has been shown to reduce skin photoaging and wrinkling. In one clinical study, a cream with Boswellia extract improved fine lines, elasticity, and skin roughness compared to placebo [17]. The anti-inflammatory and antioxidant properties are believed to mitigate UV damage responses.

The illustrated summary of the cosmetic uses of B. Serrata

The illustrated summary of the cosmetic uses of B. Serrata [18].

Research shows the potent anti-inflammatory and antioxidant properties of Boswellia serrata [19-23]. The boswellic acids inhibit pro-inflammatory enzymes like 5-LOX and human leukocyte elastase. Boswellia extract also exhibits free radical scavenging activity and boosts the body's antioxidant defenses. These combined actions suppress inflammation and may confer therapeutic benefits for inflammatory diseases.

Current evidence also suggests that Boswellia extract is an effective and safe treatment option for osteoarthritis due to its anti-inflammatory, anti-arthritic, and analgesic effects [24]. Moreover, topical treatment appears to result in significant increases in synovial concentration and therapeutic efficacy thereby confirming its transdermal application and the potential to be a disease-modifying agent in osteoarthritis [25]. Another study found that boswellic acids decreased pain severity and improved function in patients with knee osteoarthritis [26].

Elevated C-reactive protein (CRP) levels appear associated with chronic migraine and especially evident in people with migraine with aura [27]. Boswellia extract can significantly decrease CRP levels [28], which may mitigate migraine frequency and severity. A clinical trial also found that Boswellia extract reduced pain intensity and frequency in patients with chronic cluster headaches [29]. The anti-inflammatory effects likely contribute to Boswellia's efficacy for headache disorders.

Studies also report synergistic effects of combining Boswellia serrata extract with curcumin. This combination found in TorqueGlide enhances anti-inflammatory, antioxidant, and analgesic activities compared to either compound alone [30, 31].

Ilex Paraguariensis

Ilex paraguariensis, commonly known as yerba mate, is a plant containing bioactive compounds such as polyphenols and xanthines that has traditionally been used to manage nerve pain, arthritis, and headache. Emerging research now demonstrates that Ilex paraguariensis extracts exhibit analgesic and anti-inflammatory properties, suggesting therapeutic potential for pain relief.

Studies show that Ilex paraguariensis and its extracts have measurable analgesic activity [32]. This is believed to be related to modulation of the noradrenergic system [33]. Noradrenaline is involved in descending inhibition of pain, and dysregulation of this neurotransmitter pathway contributes to migraine pathogenesis. Compounds in Ilex paraguariensis may act by normalizing noradrenergic signaling to reduce pain perception. One study found that it was this same modulation of the noradrenergic system that effectively promoted orofacial pain relief in mice upon the application of Ilex paraguariensis [34].

In animal models, yerba mate extract significantly alleviated neuropathic pain induced by nerve injuries [35]. It showed analgesic effects comparable to pregabalin, a first-line medication for neuropathic pain in humans and a migraine prevention treatment option. The researchers suggested yerba mate may be useful in integrative treatment plans for neuropathic pain disorders.

In addition to analgesic effects, Ilex paraguariensis exhibits anti-inflammatory properties. Aqueous extracts of yerba mate reduced inflammation markers in vitro, including nitric oxide production and gene expression of inflammatory cytokines [36]. The anti-inflammatory activity likely complements the pain-relieving effects.

Ilex paraguariensis shows an important immunomodulatory and anti-inflammatory profile

Ilex paraguariensis shows an important immunomodulatory and anti-inflammatory profile [36].

Ilex paraguariensis shows promise as a therapeutic and preventive agent for migraine, inflammatory, neuropathic, and orofacial pain conditions. The analgesic mechanisms are linked to modulation of noradrenergic pathways and anti-inflammatory effects.

Helichrysum Oil

Helichrysum oil has demonstrated anti-inflammatory, antimicrobial, and anti-allergy effects in studies [37-40]. It contains compounds like arzanol that may reduce neuroinflammation [41].

Uncaria Tomentosa

Uncaria tomentosa, also known as cat's claw due to the claw-like thorns on its stem, is a woody vine with a long history of use in traditional herbal medicine for treating inflammatory conditions. Recent research has explored the mechanisms and efficacy of Uncaria tomentosa extracts for reducing inflammatory pain.

Studies suggest that Uncaria tomentosa extracts may help provide relief from cutaneous (skin) pain [42]. In vitro experiments have shown the extract has significant activity at various pain receptor sites involved in nociception [43]. These include agonistic effects on μ-opioid, δ-opioid, and CB2 receptors, as well as antagonistic effects on PAR-2 receptors that mediate neurogenic inflammation. One study found reduced osteoarthritis pain and inflammation with use of the extract [44] and another found benefit for its use with patients with active rheumatoid arthritis [45].

In addition to pain relief, Uncaria tomentosa appears to exert anti-neuroinflammatory effects. Chronic inflammation can sensitize pain pathways in the nervous system. Compounds in cat's claw extracts block inflammatory mediators and may mitigate neuroinflammation that contributes to chronic pain [46, 47]. This anti-inflammatory activity likely complements the analgesic effects of Uncaria tomentosa.

Uncaria tomentosa represents a promising natural therapeutic for reducing inflammatory-mediated chronic pain. The combined analgesic and anti-inflammatory properties may benefit cutaneous pain as well as pain disorders associated with neuroinflammation.

The Endocannabinoid System and Migraine

The endocannabinoid system (ECS) plays a crucial role in regulating pain perception, inflammation, and neurological function throughout the body [48, 49]. This system consists of cannabinoid receptors, endocannabinoids (naturally produced by the body), and enzymes that control their function. Research indicates that the ECS is active in stress-responsive parts of the central and peripheral nervous system, working to reduce pain and alleviate neurodegenerative and inflammatory damage [49].

Studies suggest that migraine pain may be linked to dysregulation of the endocannabinoid system, a condition sometimes referred to as Clinical Endocannabinoid Deficiency (CECD) [48]. Cannabinoids like CBD and CBG work by interacting with this system, potentially helping to restore balance and reduce pain signals [49].

Endocannabinoid System

The endocannabinoid system plays a key role in regulating pain signals throughout the body

Cannabinoids and the Trigeminovascular System: Targeting Migraine Pain at Its Source

Potential targets of cannabinoids in the trigeminovascular system

Potential targets of cannabinoids in the trigeminovascular system for migraine relief

Recent groundbreaking research published in the Journal of Headache and Pain (2024) reveals that cannabinoids can interact with multiple receptors in the trigeminovascular system, which is the key neural network involved in migraine pain. This provides compelling evidence for the effectiveness of CBD and CBG in TorqueGlide's formula.

The Trigeminovascular System: Where Migraine Pain Begins

The trigeminovascular system is composed of afferent trigeminal nerve fibers in the meninges that innervate blood vessels and immune cells, cell bodies in the trigeminal ganglia, and central connections in the brain stem. During a migraine attack, calcitonin gene-related peptide (CGRP) is released from trigeminal sensory fibers, which promotes neurogenic inflammation and pain signals that are transmitted to the brain.

How Cannabinoids Target Multiple Pathways in Migraine

TorqueGlide's CBD BSO and CBG formula works through several mechanisms identified in current research:

  • CB1 and CB2 Receptor Activation: Cannabinoids interact with CB1 receptors on trigeminal neurons and CB2 receptors on immune cells to suppress CGRP release and reduce neurogenic inflammation
  • Immune Cell Modulation: CBD and CBG target macrophages, monocytes, mast cells, and other immune cells in the meninges that contribute to neuroinflammation during migraine attacks
  • Reduced Neuronal Sensitization: By modulating pain signaling pathways, cannabinoids can prevent the sensitization of trigeminal neurons that leads to migraine pain
  • Mast Cell Stabilization: Research shows that cannabinoids can reduce meningeal mast cell degranulation, which is a key contributor to neurogenic inflammation in migraine

Studies have shown that deficiency in endocannabinoid levels is associated with migraine susceptibility. By applying CBD and CBG topically with TorqueGlide, these compounds can directly target the peripheral nerve endings and immune cells involved in migraine pathogenesis, potentially interrupting the pain cycle before it escalates.

The 2024 Journal of Headache and Pain review highlights that cannabinoids can reduce mast cell degranulation and shift macrophages to an anti-inflammatory state. In fact, one preclinical study demonstrated that a synthetic cannabinoid reduced meningeal mast cell degranulation in a migraine model, which is precisely the kind of targeted relief that TorqueGlide's formula aims to provide.

Concentration Matters: Therapeutic Dosing with TorqueGlide

For topical cannabinoid preparations to be effective against stubborn pain conditions like migraine, arthritis, and neuropathic pain, research shows that the concentration must be substantial enough to overcome the skin's barrier function and reach therapeutic levels in underlying tissues. The 1000 mg each of CBD BSO and CBG in TorqueGlide's enhanced formula represents a therapeutic-grade concentration that significantly exceeds most consumer CBD topicals.

When applied to the temples, forehead, neck, or other areas of pain, this potent formula creates a sufficient concentration gradient to:

  • Penetrate multiple skin layers to reach nerve endings and inflamed tissues
  • Activate cannabinoid receptors in skin, muscle, and peripheral nerves
  • Modulate pain signals through multiple pathways simultaneously
  • Deliver sustained relief as the skin slowly releases cannabinoids into underlying tissues

This high-potency approach sets TorqueGlide apart from diluted CBD products that may not contain sufficient active ingredients to deliver noticeable results for serious pain conditions.

How CBD BSO Enhances TorqueGlide's Effectiveness

Broad Spectrum CBD Oil (BSO) contains a wide range of beneficial cannabinoids and compounds from the hemp plant without THC, making it non-psychoactive and suitable for daily use. CBD works by targeting endocannabinoid receptor activity, reducing inflammation, and interacting with neurotransmitters involved in pain signaling.

CBD may also increase the body's levels of anandamide, a natural compound associated with regulating pain, which can reduce pain perception and improve mood. Additionally, it may limit inflammation in the brain and nervous system, benefiting those experiencing pain, insomnia, and certain immune responses.

Why Broad Spectrum CBD Oil (BSO) Over Full Spectrum or CBD Isolate

TorqueGlide's new formula specifically uses Broad Spectrum CBD Oil (BSO) rather than full spectrum CBD or CBD isolate for several important therapeutic advantages:

Key Advantages of Broad Spectrum CBD Oil

  • Entourage Effect Without THC: BSO contains multiple cannabinoids and beneficial compounds that work together synergistically (known as the "entourage effect"), but without the THC that's present in full spectrum products. This means you get enhanced therapeutic benefits without any psychoactive effects or risk of THC showing up on drug tests.
  • More Complete Relief Than Isolate: Unlike CBD isolate (which contains only pure CBD), BSO retains terpenes, flavonoids, and minor cannabinoids that significantly enhance its therapeutic potential for pain and inflammation.
  • Enhanced Absorption: The natural plant compounds in BSO can improve bioavailability and absorption compared to isolated CBD, making it more effective when applied topically.
  • Balanced Effects: The presence of multiple cannabinoids creates a more balanced effect on the endocannabinoid system, potentially providing more complete relief from various pain mechanisms.

Localized Relief with CBD BSO

  • Reduces neuroinflammation at the site of pain
  • Decreases inflammatory cytokines that contribute to migraine
  • Supports natural endocannabinoid function
  • Works synergistically with other TorqueGlide ingredients

The Unique Benefits of CBG

  • Provides powerful anti-inflammatory effects
  • Offers neuroprotective properties
  • Creates more noticeable calming effects than CBD alone
  • Particularly beneficial during active migraine attacks

Impact on Immune Cells for Comprehensive Relief

  • Reduces mast cell degranulation that triggers migraine-associated inflammation
  • Shifts macrophages toward an anti-inflammatory M2 phenotype
  • Regulates the release of pro-inflammatory cytokines
  • Targets multiple immune cell types for comprehensive migraine relief

The Synergistic Effect: Better Together

The combination of CBD and CBG at therapeutic 1000 mg concentrations creates a powerful entourage effect. Research indicates that cannabinoids may work better together than individually. A recent clinical trial found that a CBD+THC combination was superior to placebo for migraine pain relief, pain freedom, and freedom from photophobia and phonophobia at 2 hours post-treatment [6].

While our formula uses CBG instead of THC (avoiding any psychoactive effects), the principle of combined cannabinoids working together remains valid. The synergistic interaction between high-potency CBD BSO, CBG, and TorqueGlide's other active ingredients creates a comprehensive approach to migraine and pain relief that addresses multiple pathways simultaneously.

Application Tips for Maximum Effectiveness

To get the most benefit from TorqueGlide's high-potency cannabinoid formula:

  1. Apply at First Sign: For migraines, apply at the first indication of an oncoming headache for preventive benefits.
  2. Target Key Areas: Apply to temples, forehead, neck, and base of skull for migraine; directly over painful areas for other conditions.
  3. Gentle Massage: After application, gently massage the area to enhance absorption through increased blood flow.
  4. Consistent Use: For chronic conditions, regular application (2-3 times daily) maintains therapeutic levels in tissues.
  5. Layer Approach: For severe pain, a slightly more generous application may be beneficial, as the high concentration ensures more active compounds reach target tissues.

Understanding the 1000 mg Potency Advantage

The decision to formulate TorqueGlide with 1000 mg each of CBD BSO and CBG is based on scientific understanding of topical cannabinoid delivery and therapeutic thresholds. When applied topically, cannabinoids must overcome the skin's natural barrier function to reach the underlying tissues where pain and inflammation occur.

Why Potency Matters in Topical CBD/CBG Applications:

  1. Bioavailability Challenge: The skin's lipophilic barrier limits the absorption of cannabinoids. Studies show that less than 10% of topically applied cannabinoids typically reach the target tissues. Our 1000 mg potency ensures that a therapeutic amount crosses this barrier.
  2. Localized Receptor Saturation: CB1 and CB2 receptors in skin tissues require sufficient cannabinoid concentrations to activate biological pathways that reduce pain and inflammation. The 1000 mg potency helps achieve optimal receptor engagement.
  3. Depth of Penetration: Higher concentrations create a stronger diffusion gradient that drives cannabinoids deeper into tissues, reaching receptors in deeper skin layers, muscle tissue, and nerve endings that are critical for pain relief.
  4. Synergistic Threshold: The entourage effect between multiple cannabinoids requires sufficient concentrations of each compound to achieve optimal synergy. The equal 1000 mg potency of both CBD and CBG enables maximum therapeutic interaction.

Unlike many topical CBD products on the market that contain minimal amounts of cannabinoids (often as low as 100-250 mg), TorqueGlide's 1000 mg potency represents a clinical-grade approach to topical pain relief. This concentration is especially important for conditions like migraine and chronic pain, where conventional low-potency formulations may fail to provide meaningful relief.


Safe, Natural, and Effective Relief

TorqueGlide with CBD BSO and CBG provides a natural alternative for migraine sufferers seeking relief without the side effects of conventional medications. CBD oil may help relieve pain and reduce inflammation, and some research suggests it might help treat migraine headaches [1, 3]. The American Migraine Foundation notes that while scientific evidence is still developing, CBD "may still be a viable topical option for some patients with joint and muscle pain associated with migraine" [8].

By adding these powerful cannabinoids to our already effective formula, TorqueGlide now offers an even more comprehensive solution for those seeking natural relief from migraines, tension headaches, and chronic pain conditions.

Experience the Enhanced TorqueGlide

The new TorqueGlide formula combines multiple natural ingredients backed by scientific research for neurological support and pain relief. The synergistic blend works through counterirritation, anti-inflammatory effects, endocannabinoid system modulation, and regulating pain signaling pathways.

Get TorqueGlide Now

Try the enhanced TorqueGlide with 1000 mg CBD BSO and 1000 mg CBG today and discover how this comprehensive approach can help reduce migraine attacks, chronic pain, and support overall neurological health.

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