A longitudinal study published in the Journal of Clinical Medicine examined the relationship between gout and the risk of developing migraine disease. Researchers analyzed data from 23,137 gout patients and 92,548 matched controls in South Korea over a 16-year period.
The study found that patients with gout had a 26% higher risk of subsequently being diagnosed with migraine compared to those without gout. This heightened risk was especially strong for migraine without aura rather than migraines with aura.
The increased likelihood of migraine remained consistent even after accounting for various demographic factors like age, sex, income, lifestyle habits, and other medical conditions. The association was evident in both males and females, across income levels, in both rural and urban areas, and for those under age 70.
The findings indicate gout may be an independent risk factor for future migraine occurrence. The researchers theorize that changes in metabolism associated with gout could contribute to migraine developing.
While the study only included Koreans over the age of 40, it highlights the interconnected nature of migraine and other comorbid conditions. More research is needed on the biological mechanisms linking these disorders, however.