Brain Connectivity Changes During Migraine Cycle

This visualization represents the cyclic changes in brain connectivity throughout the migraine cycle, based on 82 functional MRI recordings from 12 patients. The graph shows how brain connectivity strength changes over time, demonstrating the "reset mode" pattern: a gradual increase during the pain-free period, peaking during the prodrome phase, followed by a sharp drop during the headache phase. In a typical person who doesn't experience migraine, brain connectivity maintains a relatively stable pattern. The communication between different brain regions would only show minor fluctuations throughout the day. These small changes might occur naturally with daily activities, such as becoming more alert during focused work, slightly decreasing during relaxation, or shifting during sleep cycles. However, unlike migraine patients, non-migraine individuals don't experience the dramatic cyclical pattern of brain connectivity rising and falling in a predictable manner. They don't have the sharp "reset" where connectivity suddenly drops, nor do they experience the gradual build-up to an extremely high level of connectivity followed by a crash. Instead, their brain maintains a more balanced and steady state of communication between regions, with changes being gentle and temporary rather than following a repeating pattern of extremes.