This study examined how insomnia severity relates to migraine disability and quality of life in 42 participants with both conditions. Results showed that each one-point increase in insomnia severity was associated with a 10% higher migraine disability score. Higher insomnia scores also correlated with decreased quality of life across all measured domains. The findings highlight the importance of addressing sleep issues in migraine patients, suggesting that treating insomnia could potentially reduce migraine-related disability and improve overall quality of life.

This large UK Biobank study followed 202,656 participants over 13.25 years to examine how dietary intake of mitochondria-related nutrients affects migraine risk. Researchers found that higher intake of niacin (vitamin B3) and vitamin B12 showed the most stable protective effects, with each standard deviation increase in niacin linked to a 3% reduction in migraine risk and vitamin B12 to a 4% reduction. Magnesium, riboflavin, thiamine, vitamin B6, and folate also demonstrated protective associations. The study suggests that optimizing dietary intake of these nutrients, which support mitochondrial function, may offer a practical strategy for migraine prevention and management.

This commentary challenges the notion that calcitonin gene-related peptide (CGRP) directly influences cortical spreading depression (CSD), the phenomenon underlying migraine aura. While CGRP is well-established in migraine pain mechanisms, the author argues that electrophysiological evidence indicates CGRP doesn't directly affect the ionic mechanisms driving CSD initiation or propagation. Studies show that CGRP-targeting drugs effectively reduce migraine pain without altering CSD characteristics. The author proposes that CGRP's primary role is in sensitizing peripheral nociceptive neurons rather than in the CSD wave itself, suggesting distinct pathways for aura and headache components of migraine.

This Brazilian study examined how adherence to the American Heart Association's Life's Essential 8 cardiovascular health factors relates to migraine in 4,312 participants. High adherence to these factors (physical activity, diet, nicotine exposure, sleep, body mass index, blood lipids, blood glucose, and blood pressure) was associated with lower odds of migraine with aura (64% reduction) and migraine without aura (44% reduction). The associations varied by sex, with females showing stronger protective effects from physical activity, sleep health, and blood pressure control, while males benefited more from diet and blood lipid management. This research suggests cardiovascular health optimization may serve as a migraine prevention strategy.

Using mouse models, this study revealed significant differences in gastrointestinal changes between episodic and chronic migraine. Both groups showed reduced food intake and body weight, but chronic migraine mice exhibited more severe intestinal damage, inflammation, and altered immune profiles. The study found elevated levels of inflammatory markers and CGRP in different parts of the digestive system depending on migraine type. These findings provide insight into why migraine patients, particularly those with chronic migraine, often experience gastrointestinal symptoms, highlighting the complex gut-brain axis involvement in migraine pathophysiology.

This retrospective study examined rimegepant (a CGRP receptor antagonist) for preventing menstrually-related migraine attacks in 39 women who took the medication daily for six days around menstruation. Results showed 64% of participants experienced reduction in migraine frequency during their perimenstrual period, with 23% achieving complete freedom from attacks. The treatment was well-tolerated with minimal side effects. This study provides preliminary evidence that short-term preventive use of rimegepant may offer an effective option for women with predictable menstrually-related migraine attacks.

This study analyzed data from over 5,000 Chinese men and U.S. national survey data to identify social factors associated with migraine or severe headache. Using machine learning models, researchers found that education level, marital status, employment status, and income were significant predictors. The XGBoost model showed the best predictive performance. Men with lower education levels, who were divorced or widowed, unemployed, and with lower income had higher odds of experiencing migraine. This research highlights the importance of addressing social determinants of health in migraine management strategies for men.

This Japanese study of 35 patients with both asthma and migraine found a significant relationship between asthma control and migraine intensity. When asthma control worsened (measured by Asthma Control Test scores and peak expiratory flow), migraine pain intensity increased correspondingly. The study also observed that improvements in asthma control correlated with reduced migraine severity. These findings suggest that optimizing asthma management may help reduce migraine burden in patients with both conditions, highlighting the interconnection between respiratory and neurological inflammatory processes.

This animal study examined how spreading depolarization (the phenomenon behind migraine aura) affects the hippocampus, a brain region involved in mood and cognition. Researchers found that spreading depolarization triggered seizure-like electrical activity in the hippocampus, with different patterns in dorsal versus ventral regions. The study suggests this mechanism may explain why some migraine patients experience seizures triggered by aura, and why migraine is associated with cognitive and mood disturbances. Understanding this connection could lead to better treatment approaches for migraine patients with comorbid epilepsy or cognitive symptoms.

This systematic review and meta-analysis of 23 randomized controlled trials involving 2,295 patients examined acupuncture's effectiveness for migraine. Compared to sham acupuncture, real acupuncture significantly reduced migraine duration by 4.36 hours, decreased the number of monthly migraine attacks, and reduced migraine days per month. Quality of life scores also improved substantially in both functional and emotional domains. The findings provide strong evidence supporting acupuncture as an effective non-pharmacological treatment option for migraine patients seeking alternatives or complementary approaches to medication.

This massive systematic review analyzed data from over 94 million pregnancies to examine cardiovascular and cerebrovascular risks in pregnant women with migraine. The results showed dramatically increased odds of stroke and transient ischemic attacks (10.45 times higher) and ischemic stroke specifically (7.14 times higher) in pregnant women with migraine. The study also found increased risks of myocardial infarction, preeclampsia, and other pregnancy complications. These findings underscore the critical importance of careful monitoring and management of pregnant women with migraine, particularly those with aura, to prevent serious vascular complications during pregnancy and the postpartum period.